Harlequins versus Exeter Chiefs is a fixture typically filled with international talent. In the opening Premiership Women’s Rugby (PWR) match, stars such as Wales and Quins wing Lisa Neumann and England-capped Exeter back row Emily Robinson were present, but 31 players from both sides were unavailable due to international duty. The league's October start, coinciding with the WXV tournaments, is due to a shortened PWR schedule this season, necessitated by the 2025 Rugby World Cup. This overlap has drawn criticism, notably from Exeter head coach Susie Appleby, who was without 16 players, while Quins were missing 15. She expressed confusion over the scheduling ahead of the PWR match.

Exeter emerged victorious, dealing a blow to Harlequins. The Clash's 'London Calling' echoed through the stadium before the game, setting the tone for a scrappy but physical encounter. Harlequins back row Nicole Wythe made an early, impactful tackle. The hosts were awarded multiple penalties in the first 15 minutes but opted for kicks to the corner and tap and gos instead of three-point options. Initial attempts failed, but Wythe eventually scored the first try. Both teams struggled in attack, with 'come on you Quins' chants underscoring their efforts. A cautious first half ended with Quins leading 7-0.

Harlequins appeared brighter at the start of the second half, but Exeter made it challenging for the London club. Second row Lauren Brooks nearly scored in the corner but was held up over the line. After nearly 14 minutes without a score, Harlequins fly-half Ella Cromack chose to kick after another Exeter penalty but missed. Exeter began to dominate, and with Quins hooker Maja Mueller in the sin bin, Taz Bricknell scored. However, Liv McGoverne's conversion attempt was legally disrupted by Lauren Torley. Quins suffered further setbacks with Izzy Mayhew and Wythe leaving due to injuries. Exeter secured a scrum penalty within kicking range, and McGoverne stepped up to win the game with an incredible comeback, breaking Quins' hearts.

Next weekend, Harlequins host defending champions Gloucester-Hartpury, and Exeter welcome Leicester Tigers. The absence of internationals will continue, as the WXV tournaments conclude on 12 October.