Jessica Pegula advanced to the semifinals of the US Open by defeating top seed Iga Swiatek in the quarterfinals, continuing the strong American performance at the tournament. Meanwhile, men's world number one Jannik Sinner defeated Daniil Medvedev to secure his place in the semi-finals. Pegula capitalized on Swiatek's numerous errors to reach her first Grand Slam semifinal with a 6-2, 6-4 victory, while Sinner overcame a challenging match to win 6-2, 1-6, 6-1, 6-4. These results mean that the US Open will see new champions this year.

Sinner's next opponent will be Jack Draper, who surprised Alex de Minaur 6-3, 7-5, 6-2 to become the first British man to reach the semifinals since 2012. Pegula, who had previously lost six Grand Slam quarterfinals, will face Karolina Muchova, who defeated Beatriz Haddad Maia 6-1, 6-4 despite being unwell. Pegula expressed her satisfaction with her performance, noting her clean play and early pressure on Swiatek.

Swiatek, the 2022 champion, struggled with her serve and made 41 unforced errors. Pegula quickly took a 4-0 lead in the first set, and although Swiatek improved in the second set, she couldn't regain control. Swiatek admitted difficulty in finding solutions to her service issues and regretted the numerous mistakes made.

Medvedev, the 2021 champion, also suffered from errors, making 57 unforced errors against Sinner. Despite winning the second set, Medvedev lost momentum and eventually handed Sinner the victory. Sinner commented on the physical nature of their match and the momentum shifts in the early sets. Draper advanced to his first Grand Slam semifinal without dropping a set, capitalizing on De Minaur's early errors and physical struggles.

Muchova, returning from a long injury layoff, showed impressive form early in her match against Haddad Maia, taking a 4-0 lead and eventually winning 6-1, 6-4. Muchova highlighted her performance in key moments and expressed hope that her illness did not affect others.