Joe Mixon rushed for 101 yards and scored a touchdown, while Nico Collins caught eight passes for 119 yards as the Houston Texans defeated the Jacksonville Jaguars. The Texans, leading the AFC South with an 8-5 record, secured their second win in five weeks, providing some momentum heading into their bye week.

Mixon carried the ball 20 times, with his eight-yard gain on third-and-five in the closing minutes proving crucial. CJ Stroud completed 22 of 34 passes for 242 yards, including a 22-yard touchdown pass to Dalton Schultz in the fourth quarter that essentially sealed the victory. This marked Houston's 12th win in their last 14 meetings with the Jaguars and their sixth consecutive win in Jacksonville.

However, the game will be remembered for linebacker Azeez Al-Shaair's controversial hit on Trevor Lawrence in the second quarter, which led to two sideline-clearing scuffles. Al-Shaair struck Lawrence with an elbow as the quarterback slid to the ground, resulting in Lawrence being carted off the field with a concussion. Mac Jones replaced Lawrence and threw for 235 yards and two touchdowns, but the Jaguars couldn't complete the comeback.

In other games, Russell Wilson threw for a season-high 414 yards and three touchdowns as the Pittsburgh Steelers defeated the Cincinnati Bengals. Sam Darnold led the Minnesota Vikings to a comeback victory over the Arizona Cardinals, while rookie Tarheen Still returned an interception for a touchdown to help the Los Angeles Chargers beat the Atlanta Falcons. Anthony Richardson's late touchdown pass secured a win for the Indianapolis Colts against the New England Patriots, and Zach Charbonnet's touchdown run helped the Seattle Seahawks defeat the New York Jets. Jayden Daniels' four touchdowns led the Washington Commanders to a victory over the Tennessee Titans.

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