Rookie Joshua Karty nailed a 37-yard field goal with just two seconds remaining, helping the Los Angeles Rams secure a thrilling 27-24 victory over the San Francisco 49ers on Sunday. Kyren Williams scored his third touchdown of the day with 1:50 left on a four-yard rush, propelling the Rams (1-2) to their second consecutive win over the 49ers (1-2) after a decade of dominance by the NFC West rivals. Jauan Jennings had a career day for the 49ers, catching 11 passes for 175 yards and three touchdowns, but it wasn't enough to prevent their first 14-point lead collapse since 2018.

Los Angeles was down 24-14 midway through the fourth quarter when Jake Moody missed a 55-yard field goal attempt for San Francisco. Matthew Stafford quickly connected with Tutu Atwell for a 50-yard gain, setting up Williams' touchdown two plays later. Ronnie Bell's dropped pass with 1:02 left could have put San Francisco in field goal range, but Xavier Smith's 38-yard punt return shifted momentum back to the Rams. A 25-yard pass interference penalty against linebacker De'Vondre Campbell set up Karty's game-winning kick.

In other games, Patrick Mahomes led the Kansas City Chiefs to a narrow victory, while Derrick Henry and Lamar Jackson powered the Baltimore Ravens past the Dallas Cowboys. Malik Willis had a standout performance for the Green Bay Packers, and Geno Smith helped the Seattle Seahawks improve to 3-0. Sam Darnold and the Minnesota Vikings continued their strong start, while Daniel Jones and the New York Giants held off the Cleveland Browns. Andy Dalton led the Carolina Panthers to their first win, and Jonathan Taylor boosted the Indianapolis Colts over the Chicago Bears.

Saquon Barkley's late touchdowns secured a win for the Philadelphia Eagles, and Justin Fields led the Pittsburgh Steelers to a 3-0 start. Jared Goff and the Detroit Lions dominated the Arizona Cardinals, while Bo Nix secured his first NFL win with the Denver Broncos.