World number one Jannik Sinner and former champion Daniil Medvedev are set for a US Open quarterfinal clash on Monday, both aiming to capitalize on the unexpected departures of Novak Djokovic and Carlos Alcaraz. Sinner, the Australian Open champion, secured his spot in the last eight for the second time by defeating US 14th seed Tommy Paul 7-6 (7/3), 7-6 (7/5), 6-1. Meanwhile, Medvedev, the 2021 champion and last year's runner-up to Djokovic, dominated Portugal's Nuno Borges 6-0, 6-1, 6-3 to reach the quarterfinals for the fifth time in six years.

Women's world number one Iga Swiatek remains in contention for her sixth Grand Slam title after a straight-sets victory over Russia's Liudmila Samsonova. Sinner, who rallied from 4-1 down in the first set to overcome Paul, anticipates a challenging match against Medvedev. "It will be another tough match with Daniil. There will be a lot of rallies so I have to be ready physically," Sinner remarked. Medvedev is the sole former champion remaining after the early exits of Djokovic and Alcaraz.

Medvedev's victory over Borges was emphatic, with the latter committing 51 unforced errors and being broken eight times. This will be the fourth meeting between Sinner and Medvedev this year, with Sinner having previously come back from two sets down to win in the Australian Open final and the Miami semifinals, while Medvedev secured a victory in their Wimbledon quarterfinal.

Jack Draper became the first British man since Andy Murray in 2016 to reach the quarterfinals, defeating Tomas Machac of the Czech Republic 6-3, 6-1, 6-2. Draper, who has only been broken once in four matches, praised Murray's influence, stating, "He's a legend and an icon and if I have half the career that he had I will be a happy man." Draper will next face Alex de Minaur, who won an all-Australian battle with Jordan Thompson 6-0, 3-6, 6-3, 7-5.

Swiatek, the four-time French Open winner and 2022 US Open champion, marked her 100th Grand Slam match with a 6-4, 6-1 win over 16th-ranked Samsonova. She will face American sixth seed Jessica Pegula in the semifinals, having previously beaten her en route to the title two years ago. Pegula advanced to the last eight with a 6-4, 6-2 victory over Russia's Diana Shnaider.

Beatriz Haddad Maia made history as the first Brazilian woman to reach the quarterfinals since Maria Bueno in 1968, defeating former world number one Caroline Wozniacki 6-2, 3-6, 6-3. She will next face Karolina Muchova, who has yet to drop a set in the tournament and knocked out two-time champion Naomi Osaka in the second round.