The 2025 Nissan Altima will feature only one engine option. The turbocharged 2.0-liter variable-compression (VC) four-cylinder engine, along with the 248-horsepower Altima SR VC-Turbo trim, has been discontinued. With the Maxima ceasing production in 2023, the Altima SL, equipped with a 2.5-liter four-cylinder engine, now stands as Nissan's premier sedan. This model delivers 182 hp and 178 pound-feet of torque in its all-wheel-drive configuration, and slightly more power—188 hp and 180 lb-ft—with front-wheel drive. Although not particularly powerful, it offers commendable fuel efficiency.

The base S and SV trims achieve EPA ratings of 27 mpg city, 39 highway, and 32 combined with front-wheel drive, dropping to 26/36/30 with all-wheel drive. Nissan has not disclosed the reason for phasing out the VC turbo engine, but factors likely include reliability issues and sluggish sales. The National Highway Traffic Safety Administration initiated an investigation into Nissan's VC engine in December 2023 following numerous reported failures. Nissan has been contacted for comment, and updates will be provided as new information emerges.

To compensate for the loss of the SR VC-Turbo, Nissan has introduced an SV Special Edition package for the 2025 Altima. This package enhances the SV model with features such as a 12.3-inch center touchscreen, wireless phone charging, dual-zone climate control, and wireless support for Apple CarPlay and Android Auto. Aesthetically, the Special Edition includes a moonroof, rear spoiler, faux carbon fiber trim, and black 17-inch wheels. Despite these updates, there are indications that the Altima's future may be uncertain, with Automotive News suggesting its cancellation by the end of the 2026 model year.